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We would like to better understand your experiences in order to design a new Virtual Reality-based anxiety treatment that is tailored to people with epilepsy/seizures.  

If you complete our brief survey, you can enter your email to receive an e-gift card. 


You are eligible to participate if you:

  • Are 18+ 

  • Have epilepsy yourself or you are affected by it (for example, through a family member, as a personal caregiver, as a health professional, etc.) 

  • You can share details on anxiety about epilepsy/seizures.

To access the survey, click here or copy and paste this link into your browser:

Multi-Phase Research Study

Intervention Design and Pilot to Evaluate
VR-Therapy on People With Epilepsy and Related Anxiety Disorders

Over 28% of people with epilepsy struggle from at least one anxiety disorder, making anxiety the most common psychiatric comorbidity in this population. Exposure therapy can be helpful in managing anxiety in PwE and Virtual Reality (or VR) has been shown to be an effective tool for delivering ET for several anxiety disorders. 


The use of untethered-VR headsets to deliver ET in this population offers numerous potential benefits. For example, it may not be practical to do exposures in-person during COVID-19. And even outside of the pandemic, VR reduces the need for travel, which is difficult for PwE in normal circumstances as driver’s licenses are typically suspended after a confirmed seizure. It also allows for more equitable access to healthcare resources for those who may not live in urban centers and saves money and time. 


Despite these benefits, to-date, no research has been conducted to-date on VR-ET in PwE. 


We are designing and rigorously evaluating a VR-ET program administered in private residences that focuses on decreasing anxiety in PwE. 


Blocher JB, Fujikawa M, Sung C, Jackson DC, Jones JE. Computer-assisted cognitive behavioral therapy for children with epilepsy and anxiety: a pilot study. Epilepsy Behav. 2013 Apr;27(1):70-6. doi: 10.1016/j.yebeh.2012.12.014. Epub 2013 Feb 1.

Deng W, Hu D, Xu S, Liu X, Zhao J, Chen Q, Liu J, Zhang Z, Jiang W, Ma L, Hong X, Cheng S, Liu B, Li X. The efficacy of virtual reality exposure therapy for PTSD symptoms: A systematic review and meta-analysis. J Affect Disord. 2019 Oct 1;257:698-709. doi: 10.1016/j.jad.2019.07.086. Epub 2019 Jul 30.

Hingray C, McGonigal A, Kotwas I, Micoulaud-Franchi JA. The Relationship Between Epilepsy and Anxiety Disorders. Curr Psychiatry Rep. 2019 Apr 29;21(6):40. doi: 10.1007/s11920-019-1029-9. Review.

Maples-Keller JL, Yasinski C, Manjin N, Rothbaum BO. Virtual Reality-Enhanced Extinction of Phobias and Post-Traumatic Stress. Neurotherapeutics. 2017 Jul;14(3):554-563. doi: 10.1007/s13311-017-0534-y. Review.

Munger Clary HM. Anxiety and epilepsy: what neurologists and epileptologists should know. Curr Neurol Neurosci Rep. 2014 May;14(5):445. doi: 10.1007/s11910-014-0445-9. Review.

Newsom-Davis I, Goldstein LH, Fitzpatrick D. Fear of seizures: an investigation and treatment. Seizure. 1998 Apr;7(2):101-6.

Novakova B, Harris PR, Ponnusamy A, Reuber M. The role of stress as a trigger for epileptic seizures: a narrative review of evidence from human and animal studies. Epilepsia. 2013 Nov;54(11):1866-76. doi: 10.1111/epi.12377. Epub 2013 Oct 1. Review.

Siqueira NF, Oliveira FLBB, de Souza EAP. Impaired responsibility dimension of self-esteem of Brazilian adolescents with epilepsy. Epilepsy Behav. 2017 Aug;73:1-5. doi: 10.1016/j.yebeh.2017.05.009. Epub 2017 Jun 9.

Grewe P, Lahr D, Kohsik A, Dyck E, Markowitsch HJ, Bien CG, Botsch M, Piefke M. Real-life memory and spatial navigation in patients with focal epilepsy: ecological validity of a virtual reality supermarket task. Epilepsy Behav. 2014 Feb;31:57-66. doi: 10.1016/j.yebeh.2013.11.014. Epub 2013 Dec 18.

Tychsen L, Thio LL. Concern of Photosensitive Seizures Evoked by 3D Video Displays or Virtual Reality Headsets in Children: Current Perspective. Eye Brain. 2020 Feb 11;12:45-48. doi: 10.2147/EB.S233195. eCollection 2020. Review.

Wang Z, Luo Z, Li S, Luo Z, Wang Z. Anxiety screening tools in people with epilepsy: A systematic review of validated tools. Epilepsy Behav. 2019 Oct;99:106392. doi: 10.1016/j.yebeh.2019.06.035. Epub 2019 Sep 12.

Mula M. Treatment of anxiety disorders in epilepsy: an evidence-based approach. Epilepsia. 2013 Mar;54 Suppl 1:13-8. doi: 10.1111/epi.12101. Review.

Beyenburg S, Mitchell AJ, Schmidt D, Elger CE, Reuber M. Anxiety in patients with epilepsy: systematic review and suggestions for clinical management. Epilepsy Behav. 2005 Sep;7(2):161-71. Review.

Gur-Ozmen S, Leibetseder A, Cock HR, Agrawal N, von Oertzen TJ. Screening of anxiety and quality of life in people with epilepsy. Seizure. 2017 Feb;45:107-113. doi: 10.1016/j.seizure.2016.11.026. Epub 2016 Dec 6.

Hansen CP, Amiri M. Combined detection of depression and anxiety in epilepsy patients using the Neurological Disorders Depression Inventory for Epilepsy and the World Health Organization well-being index. Seizure. 2015 Dec;33:41-5. doi: 10.1016/j.seizure.2015.10.008. Epub 2015 Oct 25.

Kotwas I, McGonigal A, Bastien-Toniazzo M, Bartolomei F, Micoulaud-Franchi JA. Stress regulation in drug-resistant epilepsy. Epilepsy Behav. 2017 Jun;71(Pt A):39-50. doi: 10.1016/j.yebeh.2017.01.025. Epub 2017 May 8. Review.

Scott AJ, Sharpe L, Thayer Z, Miller LA, Hunt C, MacCann C, Parratt K, Nikpour A, Wong T, Gandy M. Design and validation of two measures to detect anxiety disorders in epilepsy: The Epilepsy Anxiety Survey Instrument and its brief counterpart. Epilepsia. 2019 Oct;60(10):2068-2077. doi: 10.1111/epi.16348. Epub 2019 Sep 27.

Lin CY, Pakpour AH. Using Hospital Anxiety and Depression Scale (HADS) on patients with epilepsy: Confirmatory factor analysis and Rasch models. Seizure. 2017 Feb;45:42-46. doi: 10.1016/j.seizure.2016.11.019. Epub 2016 Nov 29.

Seo JG, Cho YW, Lee SJ, Lee JJ, Kim JE, Moon HJ, Park SP. Validation of the generalized anxiety disorder-7 in people with epilepsy: a MEPSY study. Epilepsy Behav. 2014 Jun;35:59-63. doi: 10.1016/j.yebeh.2014.04.005. Epub 2014 May 4.

Spitzer RL, Kroenke K, Williams JB, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006 May 22;166(10):1092-7.

Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983 Jun;67(6):361-70.